Laboratoire d'Étude des Mécanismes Cognitifs (EA 3082), Institut de Psychologie, Université Lyon 2, 5, avenue Pierre Mendès-France, 69676 Bron Cedex, France.
Neuropsychol Rev. 2013 Sep;23(3):234-56. doi: 10.1007/s11065-013-9235-4. Epub 2013 Aug 1.
Apraxia is one of the cognitive deficits that characterizes Alzheimer's disease. Despite its prevalence and relevance to diagnosing Alzheimer's disease, this topic has received little attention and is without comprehensive review. The review herein is aimed to fill this gap by first presenting an overview of the impairment caused in different clinical situations: pantomime of tool use, single tool use, real tool use, mechanical problem solving, function and manipulation knowledge tasks, and symbolic/meaningless gestures. On the basis of these results, we then propose alternative interpretations regarding the nature of the underlying mechanisms impaired by the disease. Also presented are principal methodological issues precluding firm conclusions from being drawn.
失用症是阿尔茨海默病的认知缺陷之一。尽管它的普遍性和对阿尔茨海默病诊断的相关性很高，但这个话题却很少受到关注，也没有全面的综述。本文旨在通过首先介绍不同临床情况下的损伤概述来填补这一空白：工具使用的模仿、单一工具使用、真实工具使用、机械问题解决、功能和操作知识任务以及象征性/无意义的手势。在此基础上，我们提出了关于疾病损害的潜在机制本质的替代解释。还介绍了主要的方法学问题，这些问题使得无法得出确定的结论。
