血液透析对动静脉pH值和二氧化碳分压差值的影响

Changes of arterio-venous differences in pH and pCO2 by hemodialysis.

作者信息

Agroyannis B, Tzanatos H, Konstadinidou I, Tsoutsos D, Tserkezis G, Logothetis E, Koutsikos D

机构信息

Nephrological Center, Aretaieon University Hospital, Athens, Greece.

出版信息

Int J Artif Organs. 1993 Oct;16(10):716-9.

PMID:8125618

Abstract

Normally the differences in arterial-venous pH (A-VpH) and veno-arterial pCO2 (V-ApCO2) are small and constant. This study deals with A-VpH and V-ApCO2 and their effect on arterial-venous saturation hemoglobin percentage (A-VSHb%) in uremic patients under hemodialysis (HD). In 17 uremic patients under HD with acetate, blood samples were collected anaerobically in heparinized syringes from artery (fistula) and vein (forearm without fistula) pre- and post-HD. In these samples pH, pCO2 and SHb% were determined and A-VpH, V-ApCO2 and A-VSHb% were estimated. Comparison between the values pre- and post-HD of A-VpH, V-ApCO2 and A-VSHb% shows that these three values were decreased significantly post-HD (p < 0.001). The correlation of all values (pre- and post-HD) of A-VpH and V-ApCO2 with that of A-VSHb% was significant and positive (r = 0.514 p < 0.01, r = 0.505 p < 0.01, respectively).

摘要

正常情况下，动脉 - 静脉pH值（A - VpH）和静脉 - 动脉二氧化碳分压（V - ApCO2）的差异很小且恒定。本研究探讨了A - VpH和V - ApCO2及其对血液透析（HD）的尿毒症患者动脉 - 静脉血氧饱和度血红蛋白百分比（A - VSHb%）的影响。在17例接受醋酸盐血液透析的尿毒症患者中，于血液透析前后分别从动脉（瘘管）和静脉（无瘘管的前臂）用肝素化注射器进行厌氧采血。测定这些样本中的pH值、pCO2和SHb%，并估算A - VpH、V - ApCO2和A - VSHb%。血液透析前后A - VpH、V - ApCO2和A - VSHb%值的比较表明，血液透析后这三个值均显著降低（p < 0.001）。A - VpH和V - ApCO2的所有值（血液透析前后）与A - VSHb%的相关性均显著且呈正相关（r分别为0.514，p < 0.01；r为0.505，p < 0.01）。