Nakata K, Nakatani T, Nakamori Y
Department of Respiratory Medicine, Toranomon Hospital.
Nihon Rinsho. 1994 Feb;52(2):446-50.
Silent aspiration would be major factor which predispose the bacterial infections in aged patients. Sixty-seven strains were isolated from culture positive cases. Anaerobes, S. pneumoniae, S. aureus, P. aeruginosa were the more frequently isolated strains of bacteria. Gram-negative rods were apparent in 39%, and Anaerobes were 19%, of 67 strains. Patients with diffuse panbronchiolitis are frequently affected by P. aeruginosa superinfection. The patients with longer duration, more severe lung function and more deteriorated roentgenological findings developed P. aeruginosa superinfection more easily. These infection in the lower respiratory tract significantly affect the prognosis of DPB patients. Using long-term administration of erythromycin against DPB, acute exacerbation were controlled in some patients and the frequency of their admission to hospital was lessened.
隐性误吸可能是老年患者易发生细菌感染的主要因素。从培养阳性病例中分离出67株菌株。厌氧菌、肺炎链球菌、金黄色葡萄球菌、铜绿假单胞菌是较常分离出的细菌菌株。67株菌株中，革兰氏阴性杆菌占39%，厌氧菌占19%。弥漫性泛细支气管炎患者常受到铜绿假单胞菌的重叠感染。病程较长、肺功能较差、影像学表现较差的患者更容易发生铜绿假单胞菌重叠感染。这些下呼吸道感染显著影响弥漫性泛细支气管炎患者的预后。对弥漫性泛细支气管炎患者长期使用红霉素治疗，部分患者的急性加重得到控制，住院频率降低。
