果蝇黑腹果蝇缺口位点的负互补。
Negative complementation at the notch locus of Drosophila melanogaster.
作者信息
Foster G G
出版信息
Genetics. 1975 Sep;81(1):99-120. doi: 10.1093/genetics/81.1.99.
Abstract
Four Abruptex alleles (AxE1, AxE2, Ax9B2, and Ax16172) have been mapped within the Notch locus. Based on their visible phenotypes and their interactions with one another and with N mutations, the Ax alleles can be divided into two groups. Heterozygous combinations of members of the same group are intermediate in phenotype compared to the respective homozygotes, whereas heterozygotes of Ax alleles from different groups exhibit negative heterosis, being much less viable and more extremely mutant than either homozygote. It is suggested that the Notch locus is a multi-functional regulator ("integrator") gene, whose product possesses both "repressor" and "activator" functions for the processes it regulates.
摘要
四个Abruptex等位基因（AxE1、AxE2、Ax9B2和Ax16172）已被定位在Notch基因座内。根据它们的可见表型以及它们彼此之间以及与N突变的相互作用，Ax等位基因可分为两组。同一组成员的杂合组合在表型上介于各自的纯合子之间，而来自不同组的Ax等位基因的杂合子表现出负杂种优势，其生存能力远低于纯合子，且突变程度比任何一个纯合子都更极端。有人提出，Notch基因座是一个多功能调节（“整合”）基因，其产物对其所调节的过程同时具有“抑制”和“激活”功能。
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