de Celis José Félix, Marí-Beffa Manuel, García-Bellido Antonio
Centro de Biología Molecular, Consejo Superior de Investigaciones Cientificas, Facultad de Ciencias, Universidad Autónoma de Madrid, Canto Blanco, E-28049, Madrid, Spain.
Rouxs Arch Dev Biol. 1991 Mar;200(2):64-76. doi: 10.1007/BF00637186.
Cell-cell interactions play a fundamental role in the differentiation of nervous elements in constant patterns, both during embryogenesis and imaginal development. In this paper we analyse the role of genes of theachaete-scute andEnhancer of split complexes, plus the genesextramacrochaetae, Notch, Delta, andHairless in the patterning of sensory elements in the mesonotum ofDrosophila. The phenotypes of different alleles of these genes, including lethals in genetic mosaics, reveal their participation in two processes, the singling out from epidermal cells of sensory organ mother cells and their subsequent differentiation. Studies of allelic combinations of different genes lead to a model of the genetic interactions involved in the processes of pattern formation. In this model, theachaete-scute complex plays a central role, determining sensory organ mother cells and preventing neighbouring cells from following the same developmental pathway.
细胞间相互作用在胚胎发育和成虫发育过程中，以恒定模式对神经元件的分化起着根本性作用。在本文中，我们分析了无刚毛-小盾片复合体基因、分裂增强子复合体基因，以及额外大刚毛基因、Notch基因、Delta基因和无毛基因在果蝇中胸背板感觉元件模式形成中的作用。这些基因不同等位基因的表型，包括遗传嵌合体中的致死等位基因，揭示了它们参与两个过程，即从表皮细胞中挑选出感觉器官母细胞及其随后的分化。对不同基因等位基因组合的研究得出了一个参与模式形成过程的遗传相互作用模型。在这个模型中，无刚毛-小盾片复合体起着核心作用，决定感觉器官母细胞并阻止相邻细胞遵循相同的发育途径。
