Yamadera H, Kato M, Ueno T, Tsukahara Y, Okuma T
Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.
Pharmacopsychiatry. 1993 Nov;26(6):254-8. doi: 10.1055/s-2007-1014363.
The effects of diazepam on the EEG were studied by means of EEG topographic mapping, using recordings with four different references. Subjects were ten healthy, right-handed, male volunteers aged 21-25 years. Double-blind crossover trials with a single oral dose of 10 mg diazepam and placebo controls were conducted in random sequence at intervals of one week. Four referential derivations--ipsilateral earlobe (A1A2), average reference (AV), source derivation (SD), and balanced noncephalic electrode (BNE)--were used. One-minute vigilance-controlled EEGs before drug administration and two hours after drug administration were analyzed using Fourier transformation; absolute power and relative power were calculated for four frequency bands. Diazepam caused a widespread increase of beta-frequency relative power, and a widespread decrease of theta-frequency absolute power when A1A2 and SD were taken as references. From the comparison of different reference electrodes we conclude that the selection of the reference and of spectral parameters (absolute power or relative power) play an important role in pharmaco-EEG studies.
通过脑电图地形图研究地西泮对脑电图的影响，使用了四种不同参考电极的记录。受试者为10名年龄在21 - 25岁的健康右利手男性志愿者。采用单盲交叉试验，以随机顺序，间隔一周分别给予单次口服10毫克地西泮和安慰剂对照。使用了四种参考导联——同侧耳垂（A1A2）、平均参考（AV）、源导联（SD）和平衡非头部电极（BNE）。用药前及用药后两小时进行一分钟警觉性控制脑电图记录，采用傅里叶变换进行分析；计算四个频段的绝对功率和相对功率。当地西泮以A1A2和SD作为参考电极时，可引起β频段相对功率普遍增加，θ频段绝对功率普遍降低。通过不同参考电极的比较，我们得出结论，参考电极和频谱参数（绝对功率或相对功率）的选择在药物脑电图研究中起着重要作用。
