Yamadera H, Kato M, Ueno T, Suzuki H, Nakamura S, Okuma T
Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 1997 Jun;17(3):137-41.
Diazepam is a representative drug of benzodiazepines. The subjects were 9 right-handed healthy male volunteers 21 25 years of age. Double blind crossover trials with placebo control were conducted in a random sequence at an interval of 1 week. Diazepam 10 mg and placebo were administered as single oral doses. Three-minute EEGs were recorded with subjects' eyes opened before and 2 h after drug administration. One-minute out of the 3-minute EEGs was analyzed with FFT, and the absolute amplitude power (microV) was calculated. These results were subjected to Student's t-test (double difference) and displayed with topographic maps (t statistic significance probability mapping). Diazepam decreased the delta absolute amplitude power over left-parietal dominance, theta absolute amplitude power diffusely and alpha absolute amplitude power over parietal region dominance. It also increased the beta absolute amplitude power over left-antero-temporal region dominance. The EEG profiles taken with subjects' eyes open were different from those of diazepam with eyes-closed vigilance controlled concerning the degree of decrease of delta and beta activities and region of the effect on alpha activity.
地西泮是苯二氮䓬类药物的代表药物。研究对象为9名年龄在21至25岁之间的右利手健康男性志愿者。采用双盲交叉试验，以安慰剂为对照，按随机顺序进行，间隔1周。地西泮10毫克和安慰剂均采用单次口服给药。在给药前和给药后2小时，让受试者睁眼记录3分钟脑电图。对3分钟脑电图中的1分钟进行快速傅里叶变换分析，并计算绝对振幅功率（微伏）。这些结果进行了学生t检验（双差异），并用地形图（t统计显著性概率映射）显示。地西泮降低了左顶叶优势区域的δ波绝对振幅功率、广泛的θ波绝对振幅功率以及顶叶区域优势的α波绝对振幅功率。它还增加了左前颞叶区域优势的β波绝对振幅功率。在受试者睁眼状态下记录的脑电图特征与在闭眼警觉状态下服用地西泮时的脑电图特征不同，在δ波和β波活动降低程度以及对α波活动的影响区域方面存在差异。
