Michaels B M, Nunn C R, Roses D F
Department of Surgery, New York University School of Medicine, New York.
Surgery. 1994 Mar;115(3):402-5.
A case of lobular carcinoma in a male breast is described. Lobular carcinoma is a very uncommon histopathologic form of male breast cancer because of the absence of lobules in the normal male breast. The cytoarchitecture of the normal male breast can be deranged in conditions such as Klinefelter's syndrome or as a result of estrogen exposure. Lobular carcinoma of the male breast has been described in such instances where cytoarchitectural changes are likely to have occurred.
After the pathologic diagnosis was made, a fibroblast karyotype was performed to confirm a male genotype. The patient had received no hormonal therapy. The English language literature was reviewed.
This case represents the first report of lobular carcinoma in a proven genotypic male patient receiving no exogenous estrogens.
本文描述了一例男性乳腺小叶癌病例。小叶癌是男性乳腺癌一种非常罕见的组织病理学形式，因为正常男性乳腺中不存在小叶。在诸如克兰费尔特综合征等情况下或由于接触雌激素，正常男性乳腺的细胞结构可能会紊乱。男性乳腺小叶癌已在可能发生细胞结构改变的此类情况下被描述。
做出病理诊断后，进行了成纤维细胞核型分析以确认男性基因型。该患者未接受过激素治疗。对英文文献进行了综述。
本病例代表了首例在未接受外源性雌激素的经证实基因型男性患者中发生小叶癌的报告。
