Brooks M, Catalfamo J
Comparative Hematology Laboratory, Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
Thromb Haemost. 1993 Nov 15;70(5):777-80.
Bleeding times are reported in many studies using canine models, with a variety of techniques employed to adapt these tests for dogs. We evaluated a canine model of template bleeding time, the buccal mucosa bleeding time (BMBT), by examining the test's sensitivity and specificity for defects of primary hemostasis. We examined thirty-five dogs having defined defects of either primary hemostasis (Types I, II, III von Willebrand's disease, thrombasthenia, thrombopathia) or secondary hemostasis (hemophilia A and B, Factor VII deficiency). Comparisons of BMBT and cuticle bleeding time were made in a subset of these dogs. All dogs having primary hemostatic disorders had long BMBT, and all factor deficient dogs had BMBT within normal range. The BMBT in canine models appears to be a specific and sensitive test of primary hemostasis; suitable for evaluating factors affecting template bleeding time and potential efficacy and thrombogenicity of treatment regimens.
许多使用犬类模型的研究都报告了出血时间，采用了多种技术使这些测试适用于犬类。我们通过检查该测试对原发性止血缺陷的敏感性和特异性，评估了一种犬类模板出血时间模型，即颊粘膜出血时间（BMBT）。我们检查了35只患有原发性止血（I型、II型、III型血管性血友病、血小板无力症、血小板病）或继发性止血（甲型和乙型血友病、因子VII缺乏症）明确缺陷的犬只。在这些犬只的一个亚组中对BMBT和角质层出血时间进行了比较。所有患有原发性止血障碍的犬只BMBT都很长，而所有因子缺乏的犬只BMBT都在正常范围内。犬类模型中的BMBT似乎是一种对原发性止血具有特异性和敏感性的测试；适用于评估影响模板出血时间的因素以及治疗方案的潜在疗效和血栓形成性。
