Dodds W J
Mod Vet Pract. 1984 Sep;65(9):681-6.
Von Willebrand's disease, the most common, mild, inherited bleeding disorder of animals, is an autosomal trait generally causing high morbidity and low mortality and affecting many breeds of dogs. Clinical signs include hematuria, epistaxis, gingival or genital mucosal bleeding, lameness, and prolonged bleeding from cut nails or wounds. Concurrent hypothyroidism exacerbates the disease. Affected dogs and carriers should not be bred or should be tested for von Willebrand's factor before breeding. Treatment involves IV infusion of fresh whole blood or plasma, at 3-5 ml/lb, with topical use of hemostatic compounds, and avoidance of drugs that interfere with hemostasis.
血管性血友病是动物中最常见、最轻微的遗传性出血性疾病，是一种常染色体性状，通常发病率高、死亡率低，影响许多犬种。临床症状包括血尿、鼻出血、牙龈或生殖器黏膜出血、跛行以及剪指甲或伤口出血时间延长。并发甲状腺功能减退会使病情加重。患病犬和携带者不应繁殖，或在繁殖前应进行血管性血友病因子检测。治疗方法包括以每磅体重3 - 5毫升的剂量静脉输注新鲜全血或血浆，局部使用止血化合物，并避免使用干扰止血的药物。
