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通过鞘内注射对氨基甲基苯甲酸进行蛛网膜下腔出血的抗纤溶治疗。

Antifibrinolytic therapy of subarachnoid hemorrhage by intrathecal administration of p-aminomethylbenzoic acid.

作者信息

Heidrich R, Markwardt F, Endler S, Hindersin P

出版信息

J Neurol. 1978 Sep 12;219(1):83-5. doi: 10.1007/BF00313371.

DOI:10.1007/BF00313371
PMID:81287
Abstract

In patients suffering from subarachnoid hemorrhage (SAH), intrathecal administration of p-aminomethylbenzoic acid (PAMBA) was found to produce hemostatically effective concentrations of the antifibrinolytic agent in the cerebrospinal fluid (CSF). The early clinical findings speak in favor of this mode of administration.

摘要

在患有蛛网膜下腔出血（SAH）的患者中，发现鞘内注射对氨甲基苯甲酸（PAMBA）可在脑脊液（CSF）中产生具有止血效果的抗纤溶药物浓度。早期临床结果支持这种给药方式。

相似文献

1
Antifibrinolytic therapy of subarachnoid hemorrhage by intrathecal administration of p-aminomethylbenzoic acid.通过鞘内注射对氨基甲基苯甲酸进行蛛网膜下腔出血的抗纤溶治疗。
J Neurol. 1978 Sep 12;219(1):83-5. doi: 10.1007/BF00313371.
2
[Current status of intrathecal antifibrinolytic therapy with p-aminomethylbenzoic acid (PAMBA) in subarachnoid hemorrhages].
Psychiatr Neurol Med Psychol (Leipz). 1985 Dec;37(12):686-9.
3
[Intrathecal administration of antifibrinolytics in subarachnoid hemorrhage].
Cesk Neurol Neurochir. 1983 Nov;46(6):411-2.
4
[Intrathecal administration of antifibrinolytics in primary subarachnoid hemorrhage during the acute period].
Cesk Neurol Neurochir. 1987 Jan;50(1):17-23.
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[Experimental studies on the diffusion of antifibrinolytic agents in fibrin thrombi. A contribution to intrathecal antifibrinolytic therapy in subarachnoid hemorrhages].[抗纤维蛋白溶解剂在纤维蛋白血栓中扩散的实验研究。对蛛网膜下腔出血鞘内抗纤维蛋白溶解治疗的贡献]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1982;109(2):313-8.
6
[Antifibrinolytic therapy of subarachnoid hemorrhage. Permeation of oral paraaminomethylbenzoic acid in the cerebrospinal fluid].
Psychiatr Neurol Med Psychol (Leipz). 1980 Apr;32(4):214-9.
7
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[THE PHARMACOLOGIC PROPERTIES OF A NEW ANTIFIBRINOLYTIC, PARA-AMINOMETHYLBENZOIC ACID].[一种新型抗纤维蛋白溶解剂——对氨基甲基苯甲酸的药理特性]
Arch Int Pharmacodyn Ther. 1964 Nov 1;152:223-33.
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引用本文的文献

1
Subarachnoid hemorrhage and the distribution of drugs delivered into the cerebrospinal fluid. Laboratory investigation.蛛网膜下腔出血与注入脑脊液的药物分布。实验室研究。
J Neurosurg. 2009 Nov;111(5):1001-7, 1-4. doi: 10.3171/2009.2.JNS081256.
2
Benefits and risks of antifibrinolytic therapy in the management of ruptured intracranial aneurysms. A double-blind placebo-controlled study.抗纤维蛋白溶解疗法在破裂颅内动脉瘤治疗中的益处与风险。一项双盲安慰剂对照研究。
Acta Neurochir (Wien). 1990;102(1-2):1-10. doi: 10.1007/BF01402177.

本文引用的文献

1
Antifibrinolytic therapy for intracranial aneurysms.颅内动脉瘤的抗纤溶治疗。
J Neurosurg. 1968 Jan;28(1):21-3. doi: 10.3171/jns.1968.28.1.0021.
2
Preoperative management of patients with ruptured intracranial aneurysms.颅内动脉瘤破裂患者的术前管理
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3
The use of antifibrinolytic drugs to prevent early recurrent aneurysmal subarachnoid haemorrhage.使用抗纤维蛋白溶解药物预防早期复发性动脉瘤性蛛网膜下腔出血。
Acta Neurol Scand. 1973;49(2):163-75. doi: 10.1111/j.1600-0404.1973.tb01288.x.
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Letter: E-aminocaproic acid and subarachnoid haemorrhage.
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Intracranial aneurysms and subarachnoid hemorrhage. A cooperative study. Antifibrinolytic therapy in recent onset subarachnoid hemorrhage.颅内动脉瘤与蛛网膜下腔出血。一项合作研究。近期发生的蛛网膜下腔出血的抗纤溶治疗。
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6
Fibrinolytic activity in the walls of cerebral saccular aneurysms.脑囊状动脉瘤壁中的纤溶活性。
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7
[Hemostatic processes in aneurysmal hemorrhages].[动脉瘤性出血中的止血过程]
Psychiatr Neurol Med Psychol (Leipz). 1977 Mar;29(3):129-44.