对一名患有热带痉挛性截瘫/人类嗜T淋巴细胞病毒I型相关脊髓病（HAM/TSP）的韩国患者的人类嗜T淋巴细胞病毒I型（HTLV-I）分离株进行核苷酸序列分析。

Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP.

作者信息

Saito M, Moritoyo T, Park J H, Lee B I, Kim J S, Fujisawa J, Osame M, Yoshida M

机构信息

Department of Cellular and Molecular Biology, University of Tokyo, Japan.

出版信息

Yonsei Med J. 1993 Dec;34(4):321-7. doi: 10.3349/ymj.1993.34.4.321.

DOI:10.3349/ymj.1993.34.4.321

PMID:8128736

Abstract

Limited nucleotide sequences of human T-cell lymphotropic virus type I (HTLV-1) provirus isolated from the first case of a Korean patient with HTLV-I associated myelopathy and tropical spastic paraparesis (HAM/TSP) were analysed and compared with other isolates from different regions of the world. The sequences of the env, LTR regions (536bp, 690bp respectively) showed 98.7%, 99.3% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese Adult T-cell leukemia (ATL) patient. A comparison between other isolates from different geographical origins revealed that the Korean HTLV-I isolate is more closely related to Japanese isolates than to those from other geographical origins.

摘要

对从首例韩国成人T细胞白血病病毒1型（HTLV-1）相关脊髓病和热带痉挛性截瘫（HAM/TSP）患者中分离出的前病毒的有限核苷酸序列进行了分析，并与世界不同地区的其他分离株进行了比较。env、LTR区域（分别为536bp、690bp）的序列与从日本成人T细胞白血病（ATL）患者中分离出的原型HTLV-1（ATK-1）的同源性分别为98.7%、99.3%。对来自不同地理来源的其他分离株进行比较后发现，韩国HTLV-1分离株与日本分离株的关系比与其他地理来源的分离株更为密切。