Rosenberg M E, Mckenzie J K, Mckenzie I M, Junaid A, Tagatz G E
Department of Medicine, University of Minnesota, Minneapolis.
Am J Kidney Dis. 1994 Mar;23(3):427-9. doi: 10.1016/s0272-6386(12)81006-7.
Three patients developed severe ovarian hyperstimulation syndrome (OHS) as a complication of ovarian hyperstimulation for in vitro fertilization. These patients presented with ovarian enlargement, vascular volume depletion, pleural effusions, and exudative ascites. A unique feature of the ascites in OHS was the markedly elevated renin concentration, the majority of which was prorenin. We speculate the renin-angiotensin system (RAS) may play a pathophysiologic role in the localized capillary leak that develops in OHS.
三名患者因体外受精进行卵巢过度刺激而发生严重卵巢过度刺激综合征（OHS）。这些患者出现卵巢增大、血容量减少、胸腔积液和渗出性腹水。OHS腹水的一个独特特征是肾素浓度显著升高，其中大部分是肾素原。我们推测肾素-血管紧张素系统（RAS）可能在OHS中发生的局部毛细血管渗漏中起病理生理作用。
