Delbaere A, Bergmann P J, Englert Y
Department of Gynecology and Obstetrics, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
J Assist Reprod Genet. 1997 May;14(5):241-4. doi: 10.1007/BF02765823.
The purpose of this work was to investigate the ovarian renin-angiotensin system (RAS) during severe ovarian hyperstimulation syndrome (OHSS) with ascites and pleural effusion.
Two patients who developed severe OHSS after ovarian stimulation for in vitro fertilization were investigated. Both patients presented ascites and pleural effusion. Blood, ascites, and pleural fluid were simultaneously sampled during therapeutic paracentesis and thoracocentesis. Renin activity, active renin, prorenin, and angiotensin II immunoreactivity (Ang II-ir) were measured simultaneously in plasma, ascites, and pleural fluid.
Prorenin, renin activity, active renin, and Ang II-ir levels were much higher than normal plasmatic laboratory norms in the three compartments. Prorenin and Ang II-ir levels were the highest in the ascites, while they were in the same range in the pleural fluid and in the plasma.
The present findings provide additional evidence for the ovarian origin of the prorenin and Ang II-ir in the ascites of severe OHSS.
本研究旨在探讨重度卵巢过度刺激综合征（OHSS）伴腹水和胸腔积液时卵巢肾素 - 血管紧张素系统（RAS）的情况。
对两名在体外受精卵巢刺激后发生重度OHSS的患者进行研究。两名患者均出现腹水和胸腔积液。在治疗性腹腔穿刺和胸腔穿刺过程中同时采集血液、腹水和胸水样本。同时测定血浆、腹水和胸水中的肾素活性、活性肾素、肾素原和血管紧张素II免疫反应性（Ang II - ir）。
三个腔室中的肾素原、肾素活性、活性肾素和Ang II - ir水平均远高于正常血浆实验室标准。腹水的肾素原和Ang II - ir水平最高，而胸水和血浆中的水平处于同一范围。
本研究结果为重度OHSS腹水中肾素原和Ang II - ir的卵巢来源提供了更多证据。
