Bennett M W, Shah M V, Bembridge J L
General Infirmary, Leeds.
Anaesthesia. 1994 Feb;49(2):155-6. doi: 10.1111/j.1365-2044.1994.tb03376.x.
Twenty patients, scheduled for minor gynaecological surgery, were studied. Anaesthesia was induced with propofol and maintained with oxygen, nitrous oxide and enflurane. Patients were randomly allocated to two groups: group 1 were given alfentanil 0.2 mg; group 2 were given morphine 5 mg. The rate of gastric emptying was measured indirectly by the paracetamol absorption technique. The results showed that morphine caused greater delay in gastric emptying compared with alfentanil (p < 0.05). The observed effect on gastric emptying rate may potentially affect the risk of peri-operative regurgitation and aspiration. This study provides further evidence that in short day-case procedures, when oral medication may be required postoperatively, alfentanil may be preferable to morphine as an intra-operative opioid.
对20名计划进行小型妇科手术的患者进行了研究。采用丙泊酚诱导麻醉，并用氧气、氧化亚氮和安氟醚维持麻醉。患者被随机分为两组：第1组给予阿芬太尼0.2毫克；第2组给予吗啡5毫克。通过对乙酰氨基酚吸收技术间接测量胃排空率。结果显示，与阿芬太尼相比，吗啡导致胃排空延迟更明显（p<0.05）。观察到的对胃排空率的影响可能会潜在地影响围手术期反流和误吸的风险。这项研究提供了进一步的证据，即在短期日间手术中，当术后可能需要口服药物时，作为术中阿片类药物，阿芬太尼可能比吗啡更可取。
