西沙必利与甲氧氯普胺对吗啡引起的胃排空延迟影响的比较。
Comparison of the effect of cisapride and metoclopramide on morphine-induced delay in gastric emptying.
作者信息
Rowbotham D J, Bamber P A, Nimmo W S
机构信息
Department of Anaesthesia, Sheffield University Medical School.
出版信息
Br J Clin Pharmacol. 1988 Dec;26(6):741-6. doi: 10.1111/j.1365-2125.1988.tb05313.x.
Abstract
- The effects of metoclopramide or cisapride on morphine-induced delay in gastric emptying in patients before surgery were compared. 2. Forty patients were allocated randomly to receive one of four premedications i.m.: placebo only, morphine 10 mg alone, morphine 10 mg with metoclopramide 10 mg and morphine 10 mg with cisapride 10 mg. Gastric emptying after each premedication was assessed indirectly from the rate of absorption of oral paracetamol. 3. Cisapride 10 mg reversed the delay in gastric emptying due to morphine. Its effects were significantly greater than those of metoclopramide 10 mg.
摘要
- 比较了胃复安或西沙必利对手术前患者吗啡诱导的胃排空延迟的影响。2. 40例患者被随机分配接受四种肌肉注射术前用药之一：仅用安慰剂、单独用10毫克吗啡、10毫克吗啡加10毫克胃复安以及10毫克吗啡加10毫克西沙必利。通过口服对乙酰氨基酚的吸收速率间接评估每种术前用药后的胃排空情况。3. 10毫克西沙必利逆转了吗啡引起的胃排空延迟。其效果明显大于10毫克胃复安。
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