Schwender D, Klasing S, Madler C, Pöppel E, Peter K
Institute of Anaesthesiology, University of Munich, Germany.
Anaesthesia. 1994 Feb;49(2):99-104. doi: 10.1111/j.1365-2044.1994.tb03362.x.
The effect of thiopentone on the middle latency auditory evoked potentials was investigated in 12 patients during induction of anaesthesia with thiopentone 5 mg.kg-1. 100% oxygen was administered throughout the induction, and when the patient moved purposefully a further bolus (2 mg.kg-1) was given, and anaesthesia continued in the normal way. The middle latency auditory evoked potentials were elicited before and during the induction. Binaural clicks (70 dB above normal hearing threshold) were presented at a rate of 9.3 per s. Averages of 1000 responses were analysed off line, and a fast Fourier transformation of the middle latency auditory evoked potentials were used to calculate the power spectrum of the averages. Awake, the patients had large peak to peak amplitudes and a normal waveform. The power spectra showed a high energy between 30-40 Hz. After induction the latencies of waves Na, Pa, Nb and P1 and the amplitudes of the waves Na/Pa, Pa/Nb, and Nb/P1 were decreased or completely attenuated. Both effects lasted for 4 min. When movement occurred (after 4-6 min), the values returned to awake. The second bolus repeated the changes.
在12例患者静脉注射硫喷妥钠5mg.kg-1诱导麻醉过程中，研究了硫喷妥钠对中潜伏期听觉诱发电位的影响。诱导过程中持续吸入100%氧气，当患者出现自主运动时，再给予一次硫喷妥钠推注（2mg.kg-1），然后按常规方式继续麻醉。分别在诱导前和诱导过程中引出中潜伏期听觉诱发电位。以每秒9.3次的频率给予双耳短声（比正常听阈高70dB）。离线分析1000次反应的平均值，并通过对中潜伏期听觉诱发电位进行快速傅里叶变换来计算平均值的功率谱。清醒时，患者的波峰间振幅较大，波形正常。功率谱显示在30 - 40Hz之间能量较高。诱导后，波Na、Pa、Nb和P1的潜伏期以及波Na/Pa、Pa/Nb和Nb/P1的振幅均降低或完全消失。这两种效应均持续4分钟。当出现自主运动时（4 - 6分钟后），各项指标恢复到清醒时水平。再次给予推注后重复出现上述变化。
