Danziger L H, Schoonover L L, Kale P, Resnick D J
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago 60612.
Am Surg. 1994 Apr;60(4):296-9.
Eikenella corrodens is a facultative anaerobe found as normal flora in the oral cavity, gastrointestinal system, and genitourinary tracts. It is most often associated with infections of the head and neck or those due to human bite wounds. However, the organism can be an important pathogen in intra-abdominal infections. Our case report and review of the literature revealed 19 cases of E. corrodens infections of the intra-abdominal cavity. The most common intra-abdominal site of infection was the appendix, noted in seven of the 19 reported cases. Abscess formation was noted in 15 of the 19 reports. The clinical course of the infection in most patients appeared to be indolent, evolving over several days. The majority (11 of 19) of patients described in these cases were less than 25 years old. E. corrodens is usually found concomitantly with other organisms. There appears to be a specific association between E. corrodens and streptococcal species. The drugs of choice for treatment of infections due to E. corrodens are ampicillin, penicillin, or a second generation cephalosporin. This organism is resistant to drugs traditionally active against anaerobic organisms, such as clindamycin and metronidazole.
腐蚀埃肯菌是一种兼性厌氧菌，作为正常菌群存在于口腔、胃肠道系统和泌尿生殖道中。它最常与头颈部感染或人咬伤所致感染相关。然而，该菌在腹腔感染中可能是一种重要的病原体。我们的病例报告及文献回顾显示，有19例腹腔腐蚀埃肯菌感染病例。腹腔内最常见的感染部位是阑尾，在19例报告病例中有7例。19份报告中有15份提到有脓肿形成。大多数患者感染的临床病程似乎进展缓慢，持续数天。这些病例中描述的大多数患者（19例中的11例）年龄小于25岁。腐蚀埃肯菌通常与其他微生物同时存在。腐蚀埃肯菌与链球菌属之间似乎存在特定关联。治疗腐蚀埃肯菌所致感染的首选药物是氨苄西林、青霉素或第二代头孢菌素。该菌对传统上对厌氧菌有效的药物如克林霉素和甲硝唑耐药。
