Perrigo G, Belvin L, Quindry P, Kadir T, Becker J, van Look C, Niewoehner J, vom Saal F S
Division of Biological Sciences, University of Missouri-Columbia 65211.
Behav Genet. 1993 Nov;23(6):525-31. doi: 10.1007/BF01068143.
Infanticide is a reproductive strategy found in many mammals, especially rodents. The proportion of male and female house mice (Mus domesticus) that are either infanticidal or noninfanticidal is strain specific and varies widely from stock to stock. Male house mice also show strain-specific variation in the behavioral mechanisms that inhibit infanticidal individuals from killing their own offspring. The adult offspring generated from reciprocally crossed CF-1 and Wild stock house mice were tested for their behavior toward newborn pups. In male CF-1 x Wild hybrids, the proportion of infanticidal and noninfanticidal males matched with their maternal phenotype, whereas female CF-1 x Wild hybrids exhibited a proportion of behaviors typical of the CF-1 phenotype, regardless of their mother's genotype. Our results suggest three conclusions: first, that infanticide is a highly labile and heritable behavior in both sexes; second, that there is a sex difference in the genetic substrate that regulates the inheritance of infanticidal behavior; and third, that selection pressures in male mice may operate independently on the mechanisms that promote spontaneous infanticidal behavior versus the mechanisms that inhibit infanticide.
杀婴行为是许多哺乳动物，尤其是啮齿动物中存在的一种繁殖策略。具有杀婴行为或无杀婴行为的雄性和雌性家鼠（小家鼠）的比例具有品系特异性，不同种群之间差异很大。雄性家鼠在抑制有杀婴行为的个体杀死自己后代的行为机制上也表现出品系特异性差异。对由CF-1品系和野生种群家鼠相互杂交产生的成年后代进行了测试，观察它们对新生幼崽的行为。在雄性CF-1×野生杂交种中，有杀婴行为和无杀婴行为的雄性比例与其母本表型相符，而雌性CF-1×野生杂交种则表现出一定比例的CF-1表型典型行为，无论其母亲的基因型如何。我们的研究结果得出三个结论：第一，杀婴行为在两性中都是一种高度不稳定且可遗传的行为；第二，在调节杀婴行为遗传的遗传底物上存在性别差异；第三，雄性小鼠中的选择压力可能在促进自发杀婴行为的机制与抑制杀婴行为的机制上独立起作用。
