Desmond M M, Fisher E S, Vorderman A L, Schaffer H G, Andrew L P, Zion T E, Catlin F I
J Pediatr. 1978 Oct;93(4):584-91. doi: 10.1016/s0022-3476(78)80892-0.
The neurologic course of congenital rubella syndrome was traced in 29 nonretarded children to 9 to 12 years. During the first two years, manifestations involved abnormal tone and reflexes (69%), motor delays (66%), feeding difficulties (48%), and abnormal clinical behavior (45%). Hearing loss was documented in 76%. From three to seven years, poor balance, motor incoordination (69%), and behavioral disturbances (66%) predominated. Hearing losses increased to 86%. Currently, at 9 to 12 years, 25 have residua which include learning deficits (52%), behavioral disturbances (48%), poor balance (61%), muscle weakness (54%), and deficits in tactile perception (41%). Two additional children now have hearing loss. The encephalitic manifestations of congenital rubella syndrome are diverse. Overriding problems differ at each phase of childhood. Current deficits influence progress in educational and home environments. For these children, adequate intelligence alone does not guarantee academic success.
对29名发育正常的儿童进行了追踪，观察先天性风疹综合征的神经学病程至9至12岁。在头两年，表现包括肌张力和反射异常（69%）、运动发育迟缓（66%）、喂养困难（48%）和异常临床行为（45%）。76%的儿童有听力损失记录。在3至7岁时，平衡能力差、运动不协调（69%）和行为障碍（66%）较为突出。听力损失增加到86%。目前，在9至12岁时，25名儿童有后遗症，包括学习缺陷（52%）、行为障碍（48%）、平衡能力差（61%）、肌肉无力（54%）和触觉感知缺陷（41%）。另外两名儿童现在有听力损失。先天性风疹综合征的脑炎表现多种多样。在儿童期的每个阶段，主要问题各不相同。目前的缺陷影响在教育和家庭环境中的进展。对于这些儿童来说，仅仅有足够的智力并不能保证学业成功。
