Kaufman L D
Division of Allergy, Rheumatology, and Clinical Immunology, State University of New York at Stony Brook 11794-8161.
Arthritis Rheum. 1994 Jan;37(1):84-7. doi: 10.1002/art.1780370112.
To define the natural history and outcome of eosinophilia-myalgia syndrome (EMS) among a cohort of patients followed up at one center since the onset of their disease.
Fifty-seven patients with well-characterized EMS were evaluated prospectively at a university hospital for 21-64 months (mean 36 months).
Eighty-eight percent of the patients continue to have symptomatic disease with > 3 clinical manifestations. Fatigue (91%), muscle cramping (75%), myalgia (70%), paresthesias with objectively demonstrated hypesthesias (62%), articular symptoms (54%), scleroderma-like skin changes (44%), and proximal muscle weakness (40%) are the most common features of chronic EMS. New findings identified among this cohort include cognitive symptoms in 86% of the study group, tremor, and myoclonus.
The recognition of new manifestations in EMS and ongoing clinical disease in 88% of patients highlights the chronic nature of this disorder. Continued prospective followup of a large patient base is warranted to further define the natural history of this newly recognized illness.
确定自疾病发作以来在一个中心接受随访的一组嗜酸性粒细胞增多性肌痛综合征（EMS）患者的自然病史和结局。
在一家大学医院对57例特征明确的EMS患者进行了21至64个月（平均36个月）的前瞻性评估。
88%的患者仍有症状性疾病，伴有超过3种临床表现。疲劳（91%）、肌肉痉挛（75%）、肌痛（70%）、有客观感觉减退表现的感觉异常（62%）、关节症状（54%）、硬皮病样皮肤改变（44%）以及近端肌肉无力（40%）是慢性EMS最常见的特征。在该队列中发现的新表现包括86%的研究组患者出现认知症状、震颤和肌阵挛。
认识到EMS的新表现以及88%的患者存在持续性临床疾病，突出了这种疾病的慢性本质。有必要对大量患者进行持续的前瞻性随访，以进一步明确这种新认识疾病的自然病史。
