Taylor D J
University Department of Medicine, University Hospital of South Manchester, West Didsbury, England.
Arthritis Rheum. 1994 Feb;37(2):232-5. doi: 10.1002/art.1780370212.
To identify cytokines responsible for the increased levels of tumor necrosis factor receptor (TNFR) in the joints of patients with rheumatoid arthritis.
Antibodies to TNFR types were used both to inhibit ligand cell binding and to quantify released receptors in rheumatoid synovial fibroblasts.
Binding by and shedding of the p75 TNFR was affected by interleukin-1 (IL-1), IL-4, and interferon-gamma.
IL-1 could cause increased TNF alpha binding and TNFR shedding in inflamed joints.
确定导致类风湿关节炎患者关节中肿瘤坏死因子受体（TNFR）水平升高的细胞因子。
使用针对TNFR类型的抗体来抑制配体细胞结合，并对类风湿滑膜成纤维细胞中释放的受体进行定量。
p75 TNFR的结合和脱落受白细胞介素-1（IL-1）、IL-4和干扰素-γ影响。
IL-1可导致炎症关节中TNFα结合增加和TNFR脱落。
