金刚烷胺衍生物。某些曼尼希碱的抗菌活性。
Adamantanamine derivatives. Antimicrobial activities of certain Mannich bases.
作者信息
Magarian R A, Sorenson W G
出版信息
J Med Chem. 1976 Jan;19(1):186-9. doi: 10.1021/jm00223a038.
PMID:812993
Abstract
A series of Mannich condensation products containing the beta-(1-adamantylamino)propiophenone skeleton (type I) and the o-(1-adamantylaminomethyl)phenol skeleton (type II) was synthesized and tested for antimicrobial activity against certain bacteria and fungi by the agar diffusion and tube dilution methods. Type I compounds were more active than type II compounds and had a broad-spectrum effect on certain gram-negative and gram-positive bacteria, acid-fast bacteria, a yeast, and a mold.
摘要
合成了一系列含有β-(1-金刚烷基氨基)苯丙酮骨架（I型）和邻-(1-金刚烷基氨基甲基)苯酚骨架（II型）的曼尼希缩合产物，并通过琼脂扩散法和试管稀释法测试了它们对某些细菌和真菌的抗菌活性。I型化合物比II型化合物更具活性，对某些革兰氏阴性菌、革兰氏阳性菌、抗酸菌、一种酵母和一种霉菌具有广谱作用。
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