Serban M G, Niţă V
C. Davilla University of Medicine and Pharmacy, Department of Physiopathology, Bucharest, Romania.
Rom J Intern Med. 1993 Jul-Sep;31(3):193-8.
The correlation between the circulating immune complexes (CIC) and dyslipidemia was studied in a group of 150 patients with acute ischemic stroke and 50 normal controls. The object of the study was also to find out whether these two components represent a macromolecular complex with increased atherogenic capacity or only two risk factors acting separately but achieving a summation of their atherogenic power. It can be considered that in acute ischemic stroke the presence of the two risk factors constitutes a condition of acceleration of the atherogenic process, i.e., the appearance of the vascular accident. The decrease of HDL-cholesterol detected in all the subgroups studied is probably due to the decrease of the cholesterol "reverse transport" process which favours the atherogenic process. It was found that CIC and low density lipoproteins (LDL) are risk factors which act separately determining by the effects they generate a summation of their atherogenic capacity. Cholesterol and triglycerides apparently contained in the CIC structure, can be considered as a methodologic artefact due to the use of a common reagent (PEG-6000).
在150例急性缺血性中风患者和50例正常对照组成的群体中，研究了循环免疫复合物（CIC）与血脂异常之间的相关性。该研究的目的还在于弄清楚这两个因素是代表具有增强致动脉粥样硬化能力的大分子复合物，还是仅仅是两个单独起作用但致动脉粥样硬化能力可叠加的风险因素。可以认为，在急性缺血性中风中，这两个风险因素的存在构成了动脉粥样硬化进程加速的条件，即血管意外的出现。在所有研究的亚组中检测到的高密度脂蛋白胆固醇（HDL - 胆固醇）降低，可能是由于有利于动脉粥样硬化进程的胆固醇“逆向转运”过程减弱所致。研究发现，CIC和低密度脂蛋白（LDL）是单独起作用的风险因素，它们通过各自产生的效应使致动脉粥样硬化能力叠加。由于使用了一种通用试剂（聚乙二醇6000，PEG - 6000），CIC结构中明显含有的胆固醇和甘油三酯可被视为一种方法学假象。
