Rubio G R, Mellinger R C, Zafar M S, Wolf C B
Metabolism. 1976 Jan;25(1):15-21. doi: 10.1016/0026-0495(76)90155-4.
Decrease in the blood levels of PBI, in the thyroidal uptake of iodine, and diminished effect of TRH on TSH release have been reported to occur during growth hormone administration. We assessed thyroid function indices in two groups of growth hormone deficient children before and during long-term HGH therapy. Eight patients were given TSH prior and at 2, 4, and 6 mo of growth hormone treatment. In four other children, the disposal rates of simultaneously administered I125-T4 and I131-T3 were measured before and at 2 and 6 mo after initiation of HGH replacement. Blood levels of TSH, T3, T4, TBG capacity, and the T3 resin uptake were obtained at the time of each study. Growth hormone therapy did not affect the blood levels of T4, T3, TSH, TBG capacity, the T3 resin uptake, the thyroidal response to exogenous TSH, nor the disposal rates of thyroid hormones.
据报道，在生长激素给药期间，血清蛋白结合碘（PBI）水平下降、甲状腺对碘的摄取减少以及促甲状腺激素释放激素（TRH）对促甲状腺激素（TSH）释放的作用减弱。我们评估了两组生长激素缺乏儿童在长期生长激素（HGH）治疗之前和期间的甲状腺功能指标。8名患者在生长激素治疗前以及治疗2、4和6个月时接受了TSH检测。另外4名儿童在开始HGH替代治疗前以及治疗2和6个月后，测量了同时给予的I125 - T4和I131 - T3的处置率。在每次研究时获取TSH、T3、T4、甲状腺素结合球蛋白（TBG）容量以及T3树脂摄取的血液水平。生长激素治疗并未影响T4、T3、TSH的血液水平、TBG容量、T3树脂摄取、甲状腺对外源性TSH的反应以及甲状腺激素的处置率。
