Oyama T, Mitsudomi T, Yoshida Y, Mizoue T, Hamada T, Shirakusa T
Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Surg Oncol. 1993 Dec;2(6):341-7. doi: 10.1016/0960-7404(93)90065-7.
We examined nucleolar organizer regions (Ag-NOR) in 102 patients with non-small cell lung cancer (NSCLC). Ag-NOR counts were generally higher in tumours from more advanced stages, or in poorly differentiated adenocarcinomas. Six potential-prognostic indicators included sex, age, year of operation, histology, stage and Ag-NOR count. Stage and Ag-NOR counts had a significant prognostic value in the univariate analysis for 79 patients who died of their lung cancer. In the multivariate analysis, high Ag-NOR counts as well as disease stage were independently associated with a poor prognosis. Furthermore we divided patients into three groups according to their Ag-NOR counts and found that in patients with stage I and II disease higher Ag-NOR counts were associated with shortened survival. This trend did not continue in patients with stage III and IV disease.
我们检测了102例非小细胞肺癌（NSCLC）患者的核仁组织区（Ag-NOR）。Ag-NOR计数在更晚期肿瘤或低分化腺癌中通常较高。六个潜在的预后指标包括性别、年龄、手术年份、组织学、分期和Ag-NOR计数。在79例死于肺癌的患者的单因素分析中，分期和Ag-NOR计数具有显著的预后价值。在多因素分析中，高Ag-NOR计数以及疾病分期与不良预后独立相关。此外，我们根据患者的Ag-NOR计数将其分为三组，发现I期和II期疾病患者中较高的Ag-NOR计数与生存期缩短相关。这种趋势在III期和IV期疾病患者中并未持续。
