[支气管发育异常和X线隐匿性支气管源性鳞状细胞癌中核仁组织区（银染核仁组成区，Ag-NORs）的评估]

[Assessment of nucleolar organizer regions (Ag-NORs) in bronchial dysplasia and roentgenographically occult bronchogenic squamous cell carcinoma].

作者信息

Usuda K, Saito Y, Okaniwa G, Sakuma T, Handa M, Sakurada A, Endo C, Sato M, Nagamoto N, Fujimura S

机构信息

Department of Surgery, Sendai Kousei Hospital, Japan.

出版信息

Nihon Kyobu Geka Gakkai Zasshi. 1995 Jun;43(6):836-40.

PMID:7616030

Abstract

Mean argyrophil nucleolar organizer regions (Ag-NORs) per nucleus were determined on columnar epithelium, bronchial dysplasia, roentgenographically occult squamous cell carcinoma and squamous cell carcinoma with roentgenographically findings in 76 formalin-fixed, paraffin-embedded resected specimens. 1) Mean Ag-NOR counts per nucleus (mean +/- standard deviation) were 1.67 +/- 0.30 in 10 columnar epitheliums, 2.74 +/- 0.41 in 13 lesions with bronchial dysplasia, 3.75 +/- 0.59 in 57 lesions with roentgenographically occult squamous cell carcinoma and 4.44 +/- 0.51 in 14 lesions with squamous cell carcinoma with roentgenographically findings. There were significant differences between each two groups. 2) In lesions with squamous call carcinoma, mean Ag-NOR counts per nucleus of T2, T3 or T4 tumor were significantly higher than those of T1 tumor. Mean Ag-NOR counts per nucleus of N1 or N2 tumor were significantly higher than those of N0 tumor.

摘要

在76份经福尔马林固定、石蜡包埋的切除标本中，对柱状上皮、支气管发育异常、X线隐匿性鳞状细胞癌以及有X线表现的鳞状细胞癌进行了每核嗜银核仁组织区（Ag-NORs）平均数的测定。1）10例柱状上皮每核Ag-NOR计数（平均数±标准差）为1.67±0.30，13例支气管发育异常病变为2.74±0.41，57例X线隐匿性鳞状细胞癌病变为3.75±0.59，14例有X线表现的鳞状细胞癌病变为4.44±0.51。各组之间存在显著差异。2）在鳞状细胞癌病变中，T2、T3或T4期肿瘤的每核平均Ag-NOR计数显著高于T1期肿瘤。N1或N2期肿瘤的每核平均Ag-NOR计数显著高于N0期肿瘤。