Busschbach J J, Horikx P E, van den Bosch J M, Brutel de la Rivière A, de Charro F T
Centre for Health Policy and Law, Erasmus University, Rotterdam, The Netherlands.
Chest. 1994 Mar;105(3):911-7. doi: 10.1378/chest.105.3.911.
Lung transplantation is an important topic today in healthcare policy because the technique is new and costly. One of the important issues in the evaluation of lung transplantation is quality of life. The quality of life after lung transplantation must be relatively high compared with other forms of medical care to legitimize the high costs of transplantation. Quantifying the quality of life after lung transplantation and other medical therapies is possible with general measurements of quality of life. In a pilot study of six patients with cystic fibrosis, the quality of life, both before and after lung transplantation, was measured by the following five instruments: (1) standard gamble, (2) time trade-off, (3) the Karnofsky performance status, (4) the EuroQol visual analog scale, and (5) the Nottingham health profile. This pilot study demonstrates that the introduced methodology is feasible. The preliminary results suggest that the improvement in quality of life for patients with cystic fibrosis after bilateral lung transplantation is comparable to the improvement in quality of life after heart transplantation.
肺移植是当今医疗政策中的一个重要话题，因为这项技术新颖且成本高昂。肺移植评估中的一个重要问题是生活质量。与其他医疗形式相比，肺移植后的生活质量必须相对较高，才能使移植的高昂成本合理化。通过生活质量的一般测量方法，可以对肺移植及其他医学治疗后的生活质量进行量化。在一项针对6名囊性纤维化患者的试点研究中，通过以下五种工具测量了肺移植前后的生活质量：（1）标准博弈法，（2）时间权衡法，（3）卡诺夫斯基功能状态量表，（4）欧洲五维度健康量表视觉模拟评分法，以及（5）诺丁汉健康量表。这项试点研究表明所引入的方法是可行的。初步结果表明，双侧肺移植后囊性纤维化患者生活质量的改善与心脏移植后生活质量的改善相当。
