TenVergert E M, Essink-Bot M L, Geertsma A, van Enckevort P J, de Boer W J, van der Bij W
Office for Medical Technology Assessment, University Hospital Groningen, The Netherlands.
Chest. 1998 Feb;113(2):358-64. doi: 10.1378/chest.113.2.358.
To assess the change in health-related quality of life (HRQL) among Dutch lung transplant patients before and after transplantation.
Prospective longitudinal study on HRQL among 24 Dutch lung transplant patients who participated first as transplant candidates, and later as recipients in the study. This study design provides an accurate estimate of the change in HRQL as a result of lung transplantation because there is no confounding between change due to differences in composition between groups of patients at the different points of follow-up and the true change as a result of the transplantation. Patients completed self-administered questionnaires before transplantation, and at 1, 4, 7, 13, and 19 months after transplantation. The main HRQL measures were: the Nottingham health profile (NHP), the State-trait Anxiety Inventory, the Self-rating Depression Scale-Zung, the Karnofsky Performance Index, the index of well-being, and activities of daily living (ADL).
University Hospital Groningen, the Netherlands.
Before transplantation, patients report major restrictions on the dimensions mobility and energy of the NHP, a low level of experienced well-being, and depressive symptoms. In addition, patients experience difficulties in performing ADL and report a low ability to take care of themselves. About 4 months after transplantation, mobility, energy, sleep, ADL dependency level, and dyspnea were particularly positively affected by the lung transplantation. These improvements were maintained in the following 15 months.
Lung transplantation contributes positively to the HRQL of surviving patients over time.
评估荷兰肺移植患者在移植前后健康相关生活质量（HRQL）的变化。
对24名荷兰肺移植患者进行的关于HRQL的前瞻性纵向研究，这些患者最初作为移植候选人参与研究，后来作为接受者参与研究。这种研究设计能够准确估计肺移植导致的HRQL变化，因为在不同随访点患者组之间的构成差异所导致的变化与移植导致的真实变化之间不存在混杂因素。患者在移植前以及移植后1、4、7、13和19个月完成自我管理问卷。主要的HRQL测量指标包括：诺丁汉健康量表（NHP）、状态-特质焦虑量表、zung氏自评抑郁量表、卡氏功能状态评分、幸福感指数以及日常生活活动（ADL）。
荷兰格罗宁根大学医学中心。
移植前，患者报告在NHP的活动能力和精力维度上有严重受限，幸福感水平较低，且有抑郁症状。此外，患者在进行ADL时存在困难，并且报告自我照顾能力较低。移植后约4个月，肺移植对活动能力、精力、睡眠、ADL依赖程度和呼吸困难产生了特别积极的影响。这些改善在接下来的15个月中得以维持。
随着时间推移，肺移植对存活患者的HRQL有积极贡献。
