Gershbein L L, Benuck I, Shurrager P S
Oncology. 1975;31(2):103-14. doi: 10.1159/000225012.
Walker tumor cells and carcinogens were implanted into the brains of rats and L1210, P388 and Ehrlich ascites tumors, in addition to inflammatory agents and hydrocarbons, injected cortically into mice. Behavioral changes were followed in such animals by several psychological criteria, a discriminated lever-press task in rats and an exploratory task, the poke test, in rats and mice. An activity wheel was also employed for further amplification of mouse behavior. No definite changes could be discerned by these tests between rats bearing tumor or carcinogen and the respective controls as was also the case with levels of activity in the mouse. In marked contrast, mice administered tumors or kaolin cortically demonstrated significant reductions in the mean number of pokes, especially with the higher numbers of cells injected and where neurological symptoms were evident. Behavioral changes, if any, were minimal in mice with cortically implanted carcinogens.
将沃克肿瘤细胞和致癌物植入大鼠脑内，并将L1210、P388和艾氏腹水瘤，以及炎症介质和碳氢化合物皮层注射到小鼠体内。通过几种心理学标准对这些动物的行为变化进行跟踪，对大鼠采用辨别性杠杆按压任务，对大鼠和小鼠采用探索性任务即戳刺试验。还使用了活动轮来进一步放大小鼠的行为。通过这些测试，未发现荷瘤或接触致癌物的大鼠与相应对照组之间有明显变化，小鼠的活动水平也是如此。与之形成显著对比的是，皮层注射肿瘤或高岭土的小鼠平均戳刺次数显著减少，尤其是在注射细胞数量较多且出现神经症状明显的情况下。皮层植入致癌物的小鼠若有行为变化，也极为轻微。
