Gershbein L L, Benuck I, Shurrager P S
Oncology. 1975;31(1):1-16. doi: 10.1159/000225000.
The effects of tumor cells implanted into the brain of animals on survival rates and gross and microscopic brain changes have been ascertained. Walker carcinosarcoma 256 cell suspensions were injected at several brain sites in rats and leukemia L1210 and P388 and Ehrlich ascites tumor cells, intracerebrally into BDF1 mice. Such neoplasms provided for rapid and rather predictable growth increments. The survival rates were dependent on the number of cells introduced, those receiving the higher counts succumbing first. The brains of the animals revealed fairly discrete space-occupying lesions and neurological symptoms became apparent only hours before death due to intracranial pressure.
已确定将肿瘤细胞植入动物脑内对存活率以及大脑大体和微观变化的影响。将沃克癌肉瘤256细胞悬液注射到大鼠的几个脑部位，并将白血病L1210和P388以及艾氏腹水瘤细胞脑内注射到BDF1小鼠体内。这类肿瘤生长迅速且增长情况相当可预测。存活率取决于注入的细胞数量，注入细胞数量较多的动物首先死亡。动物的大脑显示出相当离散的占位性病变，并且由于颅内压升高，神经症状仅在死亡前数小时才变得明显。
