Pitcher M E, Davidson T I, Fisher C, Thomas J M
Sarcoma Unit, Royal Marsden Hospital, London, UK.
Eur J Surg Oncol. 1994 Feb;20(1):53-6.
Thirty-eight patients with sarcomas of soft tissue and bone which followed previous radiotherapy have been treated at the Royal Marsden Hospital between 1951 and 1992. The commonest reasons for initial radiotherapy were carcinoma of the breast and lymphoma, and the median time to development of sarcoma was 11 years. The only long term survivors were those who had complete surgical excision. Seven patients required forequarter amputation (30% of the extremity sarcomas) which reflects their frequent situation in the shoulder girdle and upper arm and the close proximity to the brachial plexus and vascular bundle. The overall prognosis was poor (5-year survival 30%) and probably reflects the poor prognostic factors (size, grade and tumour site) present at the time of diagnosis.
1951年至1992年间，皇家马斯登医院对38例曾接受过放疗的软组织和骨肉瘤患者进行了治疗。最初进行放疗的最常见原因是乳腺癌和淋巴瘤，肉瘤发生的中位时间为11年。唯一的长期存活者是那些接受了完整手术切除的患者。7例患者需要进行前半侧截肢（占肢体肉瘤的30%），这反映了它们在肩胛带和上臂的常见情况以及与臂丛神经和血管束的紧密相邻关系。总体预后较差（5年生存率30%），这可能反映了诊断时存在的不良预后因素（大小、分级和肿瘤部位）。
