免疫球蛋白链高变区之间的相似性。
Similarities among hypervariable segments of immunoglobulin chains.
作者信息
Wu T T, Kabat E A, Bilofsky H
出版信息
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5107-10. doi: 10.1073/pnas.72.12.5107.
Abstract
A human lambdaV (Mcg) and a human lambdaII (Vil) myeloma protein have identical sequences in their first hypervariable segments although they differ at 21 positions throughout the variable region. If a different structural gene is responsible for each subgroup, the findings favor insertion of information for the hypervariable or complementarity-determining segments.
摘要
一种人λV（Mcg）骨髓瘤蛋白和一种人λII（Vil）骨髓瘤蛋白在其第一个高变区具有相同的序列，尽管它们在整个可变区有21个位置不同。如果每个亚组由不同的结构基因负责，这些发现支持高变或互补决定区的信息插入。
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本文引用的文献
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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.本斯·琼斯蛋白和骨髓瘤轻链可变区序列分析及其对抗体互补性的影响。
J Exp Med. 1970 Aug 1;132(2):211-50. doi: 10.1084/jem.132.2.211.
2
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3
Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains.尝试在轻链和重链可变区定位互补决定残基。
Ann N Y Acad Sci. 1971 Dec 31;190:382-93. doi: 10.1111/j.1749-6632.1971.tb13550.x.
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[Structural rule of antibodies. Complete primary structure of a monoclonal immunoglobin L chain of the lambda type, subgroup II (Bence Jones protein VIL)].[抗体的结构规则。λ型II亚组单克隆免疫球蛋白L链（本斯·琼斯蛋白VIL）的完整一级结构]
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J Biol Chem. 1969 Jul 10;244(13):3550-60.
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