人κ轻链第一互补决定区的特异性与序列之间的一些相关性。
Some correlations between specificity and sequence of the first complementarity-determining segments of human kappa light chains.
作者信息
Kabat E A, Wu T T, Bilofsky H
出版信息
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4471-3. doi: 10.1073/pnas.73.12.4471.
Abstract
Examination of the sequences of the first complementarity-determining segments of the light chains of two IgM cold agglutinins agains blood group I, four monoclonal IgM antibodies against IgG proteins, and of three Bence Jones proteins provides clues for predicting which residues contribute to antibody specificity and indicates that these predictions may be tested by evaluating recovery of antibody activity and specificity when various light chains are recombined with homologous and heterologous heavy chains.
摘要
对两种针对I血型的IgM冷凝集素轻链的第一个互补决定区序列、四种针对IgG蛋白的单克隆IgM抗体以及三种本斯·琼斯蛋白进行检测，为预测哪些残基有助于抗体特异性提供了线索，并表明这些预测可通过评估当各种轻链与同源和异源重链重组时抗体活性和特异性的恢复情况来进行检验。
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