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人κ轻链第一互补决定区的特异性与序列之间的一些相关性。

Some correlations between specificity and sequence of the first complementarity-determining segments of human kappa light chains.

作者信息

Kabat E A, Wu T T, Bilofsky H

出版信息

Proc Natl Acad Sci U S A. 1976 Dec;73(12):4471-3. doi: 10.1073/pnas.73.12.4471.

DOI:10.1073/pnas.73.12.4471
PMID:826908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC431504/
Abstract

Examination of the sequences of the first complementarity-determining segments of the light chains of two IgM cold agglutinins agains blood group I, four monoclonal IgM antibodies against IgG proteins, and of three Bence Jones proteins provides clues for predicting which residues contribute to antibody specificity and indicates that these predictions may be tested by evaluating recovery of antibody activity and specificity when various light chains are recombined with homologous and heterologous heavy chains.

摘要

对两种针对I血型的IgM冷凝集素轻链的第一个互补决定区序列、四种针对IgG蛋白的单克隆IgM抗体以及三种本斯·琼斯蛋白进行检测，为预测哪些残基有助于抗体特异性提供了线索，并表明这些预测可通过评估当各种轻链与同源和异源重链重组时抗体活性和特异性的恢复情况来进行检验。

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Some correlations between specificity and sequence of the first complementarity-determining segments of human kappa light chains.人κ轻链第一互补决定区的特异性与序列之间的一些相关性。
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4471-3. doi: 10.1073/pnas.73.12.4471.
2
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Cell-diffusion precipitin analysis of mixed IgM-IgG cryoglobulins. An unusual kappa-chain determinant of the IgM component.混合性IgM-IgG冷球蛋白的细胞扩散沉淀分析。IgM成分一种不寻常的κ链决定簇。
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本文引用的文献

1
THE ACTION OF ENZYMES FROM CLOSTRIDIUM TERTIUM ON THE I ANTIGENIC DETERMINANT OF HUMAN ERYTHROCYTES.第三梭状芽孢杆菌的酶对人红细胞I抗原决定簇的作用
J Exp Med. 1963 Aug 1;118(2):175-94. doi: 10.1084/jem.118.2.175.
2
An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.本斯·琼斯蛋白和骨髓瘤轻链可变区序列分析及其对抗体互补性的影响。
J Exp Med. 1970 Aug 1;132(2):211-50. doi: 10.1084/jem.132.2.211.
3
Structure-function relationships among anti-gamma globulin antibodies.抗γ球蛋白抗体之间的结构-功能关系。
Ann N Y Acad Sci. 1971 Dec 31;190:371-81. doi: 10.1111/j.1749-6632.1971.tb13549.x.
4
Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains.尝试在轻链和重链可变区定位互补决定残基。
Ann N Y Acad Sci. 1971 Dec 31;190:382-93. doi: 10.1111/j.1749-6632.1971.tb13550.x.
5
[Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production].[抗体结构规则。κ型3亚组单克隆免疫球蛋白L链（本斯·琼斯蛋白Ti）的一级结构。IV. 完整氨基酸序列及其对抗体产生机制的意义]
Hoppe Seylers Z Physiol Chem. 1972 Feb;353(2):189-208.
6
Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI.由本斯-琼斯蛋白REI可变部分组成的二聚体的晶体结构和分子结构
Eur J Biochem. 1974 Jun 15;45(2):513-24. doi: 10.1111/j.1432-1033.1974.tb03576.x.
7
Structure of a lambda-type Bence-Jones protein at 3.5-A resolution.分辨率为3.5埃的λ型本斯-琼斯蛋白的结构
Biochemistry. 1973 Nov 6;12(23):4620-31. doi: 10.1021/bi00747a013.
8
Chemical analyses of variable regions of heavy and light chains of cold agglutinins.冷凝集素重链和轻链可变区的化学分析
Vox Sang. 1973 May;24(5):432-40. doi: 10.1111/j.1423-0410.1973.tb03484.x.
9
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Proc Natl Acad Sci U S A. 1972 Jan;69(1):40-3. doi: 10.1073/pnas.69.1.40.
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