Padmini R, Srinivasan S, Nalini P, Mahadevan S
Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
J Trop Pediatr. 1993 Dec;39(6):361-4. doi: 10.1093/tropej/39.6.361.
In order to determine the efficacy of short course chemotherapy (SCC) for tuberculosis in children, 83 newly diagnosed cases in children < 12 years old were given SCC and were prospectively followed for 1-3 years. Seventy-one cases were treated for 6-9 months as they had mild to moderate involvement. Twelve cases were treated for 12 months as they had meningitis (7), disseminated tuberculosis (2), or miliary tuberculosis (3). The results showed that none of the children, at the end of follow up, showed evidence of active tuberculosis. All children tolerated the drugs well, with side effects noticed being mild, namely transient hepatitis (4), vomiting (1), and skin rash (1). It is suggested that SCC for 6-9 months using isoniazid (INH) and rifampicin along with other drugs when necessary is highly effective in most cases of tuberculosis in children and has several advantages over conventional chemotherapy of 18 months or longer duration.
为了确定短程化疗（SCC）对儿童结核病的疗效，对83例12岁以下新诊断的儿童病例给予短程化疗，并对其进行了1至3年的前瞻性随访。71例病情为轻度至中度的患儿接受了6至9个月的治疗。12例患有脑膜炎（7例）、播散性结核病（2例）或粟粒性结核病（3例）的患儿接受了12个月的治疗。结果显示，在随访结束时，没有一名儿童有活动性结核病的迹象。所有儿童对药物耐受性良好，所发现的副作用均较轻微，即短暂性肝炎（4例）、呕吐（1例）和皮疹（1例）。建议在大多数儿童结核病病例中，必要时联合使用异烟肼（INH）、利福平及其他药物进行6至9个月的短程化疗非常有效，且与18个月或更长疗程的传统化疗相比有多个优势。
