Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, De Vos R, van den Oord J J, Collen D, Mulligan R C
Whitehead Institute of Biomedical Research, Cambridge, Massachusetts 02142.
Nature. 1994 Mar 31;368(6470):419-24. doi: 10.1038/368419a0.
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.
间接证据表明，纤维蛋白溶解系统及其生理触发因子，即组织型（t-PA）和尿激酶型（u-PA）纤溶酶原激活剂，在许多蛋白水解过程中起关键作用。t-PA基因失活会损害血凝块溶解，u-PA基因失活会导致偶尔的纤维蛋白沉积。同时缺乏t-PA和u-PA的小鼠会出现广泛的自发性纤维蛋白沉积，并对生长、生育能力和生存产生相关影响。
