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[兔化学损伤肝脏中某些分枝杆菌病的发病机制(作者译)]

[Pathogenesis of certain mycobacterioses in a chemically damaged liver of the rabbit (author's transl)].

作者信息

Dornetzhuber V, Burjanová B

出版信息

Z Erkr Atmungsorgane. 1975 Apr;143(1):61-5.

PMID:813406
Abstract

Cirrhosis of the liver was provoked in adult rabbits by the administration of CCl4/0,3 ml subcutaneously two times a week during a period of six weeks. It was found that the infection by M. tuberculosis, M. avium and M. kansasii causes a considerably greater dissemination than in the case with the livers of rabbits unaffected by cirrhosis, and that even a non-pathogenic strain (M. intracellulare) is pathogenic, if the liver is affected. Our findings confirm the lowered resistance of a chemically damaged liver to the development of mycobacterial infection.

摘要

通过每周两次皮下注射0.3毫升四氯化碳,持续六周,诱发成年兔肝硬化。结果发现,与未患肝硬化的兔肝脏相比,结核分枝杆菌、鸟分枝杆菌和堪萨斯分枝杆菌感染导致的扩散程度要大得多,而且如果肝脏受到影响,即使是非致病性菌株(胞内分枝杆菌)也具有致病性。我们的研究结果证实,化学损伤的肝脏对分枝杆菌感染发展的抵抗力降低。

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