Yuksel B, Greenough A, Gamsu H R
Department of Child Health, King's College Hospital London, UK.
Pediatr Pulmonol. 1993 Dec;16(6):358-61. doi: 10.1002/ppul.1950160607.
Respiratory morbidity in the first 6 months of life of 35 infants who had had neonatal meconium aspiration syndrome (MAS) was compared to that of 70 controls, also born at term, matched for gender and ethnic origin. The number of infants in the two groups who were symptomatic was compared. Infants were described as symptomatic if, following discharge from hospital, they had at least one episode of wheezing and/or coughing which lasted for 3 days or more. There was no significant difference between the two groups regarding parental smoking or the proportion of infants who had a family history of atopy. A significantly greater proportion of the MAS group (49%) than of the control group (20%) was symptomatic at follow-up. Eight (23%) infants with MAS and 2 (3%) controls had symptoms which necessitated regular bronchodilator therapy. The 8 infants with MAS who were on maintenance bronchodilator therapy had required significantly longer neonatal respiratory support and had larger lung volumes at follow-up than the other 27 infants. We conclude that neonatal meconium aspiration syndrome is associated with increased respiratory morbidity in the first 6 months of life.
将35例患有新生儿胎粪吸入综合征（MAS）的婴儿出生后前6个月的呼吸道发病率与70例同样足月出生、性别和种族相匹配的对照组婴儿进行比较。比较两组中有症状婴儿的数量。如果婴儿出院后至少有一次喘息和/或咳嗽发作持续3天或更长时间，则被描述为有症状。两组在父母吸烟情况或有特应性家族史的婴儿比例方面无显著差异。在随访中，MAS组有症状的比例（49%）显著高于对照组（20%）。8例（23%）患有MAS的婴儿和2例（3%）对照组婴儿有需要定期支气管扩张剂治疗的症状。接受维持性支气管扩张剂治疗的8例患有MAS的婴儿比其他27例婴儿需要显著更长时间的新生儿呼吸支持，且随访时肺容积更大。我们得出结论，新生儿胎粪吸入综合征与出生后前6个月呼吸道发病率增加有关。
