Laissy J P, Gay-Depassier P, Soyer P, Dombret M C, Murciano G, Sautet A, Aubier M, Menu Y
Department of Radiology, Hopital Bichat, Paris, France.
Radiology. 1994 Apr;191(1):263-7. doi: 10.1148/radiology.191.1.8134585.
To determine whether dynamic contrast material-enhanced magnetic resonance (MR) imaging can help differentiate between malignant and benign mediastinal lymph nodes (MLNs) in bronchogenic carcinoma.
Nine patients with biopsy-proved lung carcinoma underwent dynamic contrast-enhanced MR imaging before undergoing thoracic surgery. MR studies included spin-echo, electrocardiographically gated axial and coronal sequences and transaxial gradient-echo breath-hold sequences, which were performed after administration of a bolus of gadoterate meglumine. The enhancement curves were established on the basis of mean signal intensities from regions of interest at the level of tumor and the enlarged MLN. MR images were compared with pathologic specimens obtained at surgical resection.
Metastatic MLNs exhibited their peak enhancement at 60-80 seconds, with a slow decrease until 6 minutes. Granulomatous and anthracotic lymph nodes displayed a slight enhancement, with no peak within 6 minutes (P < .01).
Dynamic contrast-enhanced MR images may provide informative data about the nature of enlarged MLNs in the preoperative assessment of lung carcinoma. Further studies are needed to investigate its usefulness in clinical practice.
确定动态对比剂增强磁共振成像（MR）是否有助于鉴别支气管肺癌中的恶性和良性纵隔淋巴结（MLN）。
9例经活检证实为肺癌的患者在接受胸外科手术前行动态对比增强MR成像。MR检查包括自旋回波、心电门控轴位和冠状位序列以及经轴位梯度回波屏气序列，这些序列在静脉注射钆喷酸葡胺后进行。根据肿瘤层面和肿大的MLN感兴趣区的平均信号强度建立增强曲线。将MR图像与手术切除时获得的病理标本进行比较。
转移性MLN在60 - 80秒时达到增强峰值，直至6分钟缓慢下降。肉芽肿性和炭末沉着性淋巴结显示轻微增强，6分钟内无峰值（P <.01）。
动态对比增强MR图像可能为肺癌术前评估中肿大MLN的性质提供有用数据。需要进一步研究以探讨其在临床实践中的实用性。
