Bojö L, Cassuto J, Nellgård P, Jönsson A
Department of Clinical Physiology, Central Hospital, Karlstad, Sweden.
Acta Physiol Scand. 1994 Jan;150(1):67-73. doi: 10.1111/j.1748-1716.1994.tb09660.x.
We investigated the effects of adrenergic, cholinergic and vasoactive intestinal polypeptide (VIP)-ergic agonists and antagonists on the amplitude of gastric phasic contractions in the anaesthetized rat using a volumetric model. The amplitude of the phasic contractions was reduced significantly by atropine, hexamethonium or bilateral cervical vagotomy indicating that cholinergic neural activity involving both muscarinic and nicotinic receptors and intact vagal nerve function are integral parts of the control of basal gastric phasic motility. In contrast, neither selective alpha 1-, alpha 2- or non-selective beta-blockers had any significant influence on the amplitude of the gastric contractions suggesting that adrenergic neurones are not tonically active in the maintenance of basal phasic motility in the stomach. The amplitude of the gastric phasic contractions was, however, significantly reduced by the alpha 1-agonist L-phenylephrine, the alpha 2-agonist clonidine and a close intraarterial injection of VIP (3 micrograms kg-1) but not be the selective beta 1-agonist, prenalterol, or the beta 2-agonist, salbutamol. These data suggest the presence of superimposed inhibitory control of phasic activity by VIP-ergic stimulation and by adrenergic neurones via alpha-receptor stimulation.
我们使用容积模型研究了肾上腺素能、胆碱能和血管活性肠肽（VIP）能激动剂及拮抗剂对麻醉大鼠胃相性收缩幅度的影响。阿托品、六甲铵或双侧颈迷走神经切断术可显著降低相性收缩的幅度，这表明涉及毒蕈碱和烟碱受体的胆碱能神经活动以及完整的迷走神经功能是基础胃相性运动控制的组成部分。相比之下，选择性α1、α2或非选择性β阻滞剂对胃收缩幅度均无显著影响，这表明肾上腺素能神经元在维持胃基础相性运动中并非持续活跃。然而，α1激动剂L-去氧肾上腺素、α2激动剂可乐定以及动脉内近距离注射VIP（3微克/千克）可显著降低胃相性收缩的幅度，但选择性β1激动剂普瑞特罗或β2激动剂沙丁胺醇则无此作用。这些数据表明，存在由VIP能刺激以及肾上腺素能神经元通过α受体刺激对相性活动进行的叠加抑制性控制。
