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人中性粒细胞多形核粒细胞弹性蛋白酶对人免疫球蛋白的有限切割。免疫复合物疾病的可能调节因子。

Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease.

作者信息

Folds J D, Prince H, Spitznagel J K

出版信息

Lab Invest. 1978 Oct;39(4):313-21.

PMID:81354
Abstract

Human polymorphonuclear lysosomal granules contain a neutral protease which is capable of digesting human immunoglobulins. The protease is located in the azurophil granules and enzymatically cleaves IgG, producing a Fab-like piece which is recoverable. The Fc-like fragment is not crystallized. The Fab-like fragment competes effectively for ligands formed by native antibody from which the fragments were produced.

摘要

人多形核白细胞溶酶体颗粒含有一种能够消化人免疫球蛋白的中性蛋白酶。该蛋白酶位于嗜天青颗粒中，能酶解IgG，产生一种可回收的类似Fab的片段。类似Fc的片段不会结晶。类似Fab的片段能有效地竞争由产生这些片段的天然抗体形成的配体。

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1
Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease.人中性粒细胞多形核粒细胞弹性蛋白酶对人免疫球蛋白的有限切割。免疫复合物疾病的可能调节因子。
Lab Invest. 1978 Oct;39(4):313-21.
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Regulation of neutrophil functions by elastase-generated IgG fragments.弹性蛋白酶产生的IgG片段对中性粒细胞功能的调节
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Proteolysis of human IgG by human polymorphonuclear leucocyte elastase produces an Fc fragment with in vitro biological activity.人多形核白细胞弹性蛋白酶对人免疫球蛋白G的蛋白水解作用产生具有体外生物活性的Fc片段。
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Functional importance of cystic fibrosis immunoglobulin G fragments generated by Pseudomonas aeruginosa elastase.铜绿假单胞菌弹性蛋白酶产生的囊性纤维化免疫球蛋白G片段的功能重要性。
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Elastase from polymorphonuclear leucocytes: a regulatory enzyme in immune complex disease.多形核白细胞弹性蛋白酶：免疫复合物疾病中的一种调节酶。
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Mol Immunol. 1979 May;16(5):301-6. doi: 10.1016/0161-5890(79)90130-5.

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