Rehse K, Zimmermann H
Institut für Pharmazie, Freien Universität Berlin, Germany.
Arch Pharm (Weinheim). 1994 Feb;327(2):67-75. doi: 10.1002/ardp.19943270203.
Twenty-six title compounds with the ethylamine part of tryptamine or 5-methoxytryptamine fixed in an anticlinal ecliptic conformation were synthesized for assaying them at the different known serotonin receptors. Several alkylation methods have been improved and adapted for the space consuming norbornane system. The structures were fully elucidated by high-field NMR spectroscopy. All 1H- and 13C-signals could be assigned by means of 1H-1H- and 13C-1H-correlation spectroscopy (COSY).
合成了26种标题化合物，其中色胺或5-甲氧基色胺的乙胺部分固定为反式偏位构象，用于在不同已知的5-羟色胺受体上进行测定。几种烷基化方法已得到改进并适用于空间消耗大的降冰片烷体系。通过高场核磁共振光谱对结构进行了全面阐释。所有的1H和13C信号都可以通过1H-1H和13C-1H相关光谱（COSY）进行归属。
