Hirata R M, Jaques D A, Chambers R G, Tuttle J R, Mahoney W D
Ann Surg. 1975 Aug;182(2):98-103. doi: 10.1097/00000658-197508000-00002.
Evaluation and analysis of 478 cases of carcinoma of the oral cavity treated from 1947 through 1970 shows a significant improvement in radiotherapy in the supervoltage (Co60) era. Survival in the early stages of disease (I and II) improved in the supervoltage era but not in the later stages of disease (III and IV). Results with combined therapy for advanced disease showed no significant difference from that of single mode therapy, whether with radiotherapy or with surgery in the supervoltage era.
对1947年至1970年期间治疗的478例口腔癌病例的评估与分析表明，在超高压（钴60）时代，放射治疗有显著改善。疾病早期（I期和II期）的生存率在超高压时代有所提高，但疾病后期（III期和IV期）则没有。对于晚期疾病，联合治疗的结果与单一模式治疗（无论是在超高压时代采用放射治疗还是手术治疗）相比，没有显著差异。
