移植中MHC抗原的间接呈递。
Indirect presentation of MHC antigens in transplantation.
作者信息
Shoskes D A, Wood K J
机构信息
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, UK.
出版信息
Immunol Today. 1994 Jan;15(1):32-8. doi: 10.1016/0167-5699(94)90023-X.
PMID:8136009
Abstract
T cells can recognise foreign major histocompatibility complex (MHC) antigens by two distinct routes, either directly as intact molecules or indirectly as peptides after antigen processing. Danny Shoskes and Kathryn Wood review the evidence that indirect presentation of allopeptides may play a significant role in the events leading to the rejection or acceptance of allo- and xenografts.
摘要
T细胞可通过两种不同途径识别外来主要组织相容性复合体（MHC）抗原，要么直接识别完整分子，要么在抗原加工后间接识别肽段。丹尼·肖克斯和凯瑟琳·伍德回顾了相关证据，即同种异体肽的间接呈递可能在导致同种异体移植和异种移植排斥或接受的过程中发挥重要作用。
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