Valle F C, Hayashi H, Prates J C, Didio L J
Faculty of Medicine of Santo Amaro, Brazil.
Bull Assoc Anat (Nancy). 1993 Jun;77(237):39-43.
Biochemical, hematologic, histometric, structural and ultrastructural changes were studied in the thyroid gland of rats, whom were administered Lithium carbonate. It was noted that (1) the Li carbonate had a cumulative effect on the serum; (2) T3 and T4 hormones in the blood decreased throughout the experiment; (3) the red blood cells, hemoglobin, hematocrit, platelets and leukocytes decreased gradually; (4) the diameter of the thyroid follicles, the size of the follicular cells and colloid droplets decreased, whereas the stroma was invaded by a greater number of collagen fibers and blood capillaries.
对给予碳酸锂的大鼠甲状腺进行了生化、血液学、组织测量学、结构和超微结构变化的研究。结果发现：（1）碳酸锂对血清有累积效应；（2）在整个实验过程中，血液中的T3和T4激素减少；（3）红细胞、血红蛋白、血细胞比容、血小板和白细胞逐渐减少；（4）甲状腺滤泡直径、滤泡细胞大小和胶体滴减小，而基质中侵入了更多的胶原纤维和毛细血管。
