Fortier-Beaulieu M, Laquerrière A, Thomine E, Lauret P, Hémet J
Clinique Dermatologique, Centre Hospitalier Régional et Universitaire, Rouen, France.
Dermatology. 1994;188(2):94-9. doi: 10.1159/000247109.
DNA flow cytometry (FCM) was performed on archived material of 82 basal cell carcinomas (BCC), using Hedley's technique. Sixty-five samples were analysed. Biopsy samples were classified in five groups depending on their morphological differentiation: solid, cystic, adenoid, keratotic and metatypical. Two parameters were studied: proliferative index and DNA index. Statistical analysis revealed that BCC with keratinizing or metatypical differentiation had a greater amount of aneuploidy when compared with BCC without particular differentiation (solid and cystic) or aneuploid differentiation (p < 0.001). The proliferative indices were significantly different in the four groups. DNA FCM of BCC confirms the value of morphological classifications and gives another example of aneuploidy in a tumour with low aggressiveness.
采用赫德利技术，对82例基底细胞癌（BCC）的存档材料进行了DNA流式细胞术（FCM）检测。分析了65个样本。活检样本根据其形态学分化分为五组：实性、囊性、腺样、角化性和异型性。研究了两个参数：增殖指数和DNA指数。统计分析显示，与无特殊分化（实性和囊性）或非整倍体分化的基底细胞癌相比，具有角化或异型性分化的基底细胞癌非整倍体数量更多（p < 0.001）。四组的增殖指数有显著差异。基底细胞癌的DNA FCM证实了形态学分类的价值，并为低侵袭性肿瘤中的非整倍体提供了另一个例子。
