幽门螺杆菌根除前后胃窦和胃体黏膜的组织学

Histology of the mucosa of gastric antrum and body before and after eradication of Helicobacter pylori.

Resende L M, Queiroz D M, Barbosa A J, Mendes E N, Rocha G A, Coelho L G, Passos M C, Castro L P, Oliveira C A, Lima Júnior G F

Departamento de Propedêutica Complementar, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Braz J Med Biol Res. 1993 Dec;26(12):1279-89.

Abstract

Helicobacter pylori status and the histology of the antral and oxyntic mucosa were evaluated in 25 patients with duodenal ulcer treated with a triple schedule of furazolidone, metronidazole and amoxicillin, and in 16 patients treated only with cimetidine. 2. Before treatment, H. pylori was detected in all patients. One month after treatment with the antimicrobial agents, H. pylori was not found in 18 (72.0%) of 25 patients treated with the triple schedule. In the patients treated with cimetidine (N = 16) the H. pylori tests continued to be positive after treatment. 3. Inflammatory activity and intensity of gastritis were significantly reduced in patients treated with the antimicrobial agents but not in cimetidine-treated patients. Three patients who had negative cultures and improvement of gastritis 1 month after treatment became H. pylori positive again within 2 months, with concomitant reappearance of gastritis. 4. This study provides additional evidence that histological gastritis observed in H. pylori-positive patients with duodenal ulcer is due to the presence of the microorganism.

摘要

对25例接受呋喃唑酮、甲硝唑和阿莫西林三联疗法治疗的十二指肠溃疡患者以及16例仅接受西咪替丁治疗的患者的幽门螺杆菌状况以及胃窦和胃体黏膜的组织学进行了评估。2. 治疗前，所有患者均检测出幽门螺杆菌。使用抗菌药物治疗1个月后，接受三联疗法治疗的25例患者中有18例（72.0%）未检测到幽门螺杆菌。在接受西咪替丁治疗的患者（n = 16）中，治疗后幽门螺杆菌检测仍为阳性。3. 接受抗菌药物治疗的患者胃炎的炎症活动度和严重程度显著降低，但接受西咪替丁治疗的患者未出现这种情况。3例治疗1个月后培养结果为阴性且胃炎有所改善的患者在2个月内再次变为幽门螺杆菌阳性，同时胃炎再次出现。4. 本研究提供了额外证据，表明幽门螺杆菌阳性的十二指肠溃疡患者中观察到的组织学胃炎是由该微生物的存在所致。