Talebi Bezmin Abadi Amin
Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
J Pathog. 2018 May 22;2018:9064952. doi: 10.1155/2018/9064952. eCollection 2018.
as gram-negative and spiral microorganism is responsible for colonization in the gastric microniche for more than 50% of world population. Recent studies have shown a critical role of in the development of peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Over the past decade, there has been a sharp interest to use noninvasive tests in diagnosis of the infection. During the years after discovery by Marshall and Warren, it has been frequently declared that the rapid urease test (RUT) is one of the cheapest and rapid diagnostic approaches used in detecting the infection. Although the specificity and sensitivity are durable for this test, clinical experiences had shown that the ideal results are only achieved only if we take biopsies from both corpus and antrum at the same time. Given the diagnosis of the in clinical samples, gastroenterologists are facing a long list of various molecular and nonmolecular tests. We need more in-depth researches and investigations to correctly generalize rapid and accurate molecular tests determining both bacterial identity and antibiotic resistance profile.
作为革兰氏阴性螺旋微生物，它在全球超过50%人口的胃微生态环境定殖中起作用。最近的研究表明，它在消化性溃疡、胃黏膜相关淋巴组织（MALT）淋巴瘤和胃癌的发生发展中起关键作用。在过去十年中，人们对使用非侵入性检测方法诊断该感染产生了浓厚兴趣。在马歇尔和沃伦发现该菌后的数年里，快速尿素酶试验（RUT）常被宣称是检测该感染最便宜且快速的诊断方法之一。尽管该试验的特异性和敏感性持久，但临床经验表明，只有同时从胃体和胃窦取活检组织才能获得理想结果。鉴于临床样本中该菌的诊断，胃肠病学家面临着众多分子和非分子检测方法。我们需要更深入的研究和调查，以正确推广能同时确定细菌身份和抗生素耐药谱的快速准确分子检测方法。
