Paré W P, Redei E
VA Medical Center, Perry Point, Maryland 21902.
J Physiol Paris. 1993;87(4):229-38. doi: 10.1016/0928-4257(93)90010-q.
Wistar Kyoto (WKY) rats, as compared to several other rat strains, are hypoactive in the open field test and in the defensive burying test. WKY rats readily acquire a learned helplessness task as well as a passive avoidance tasks. WKY rats also reveal a greater susceptibility to restraint-induced stress ulcer. The behavioral tests suggest the presence of depressive behavior in WKY rats. When exposed to the Porsolt forced-swim test of 'behavioral despair', WKY rats are judged as exhibiting more depressive behavior. Desipramine not only reduced immobility in the forced-swim test, but also diminished the severity of restraint-induced stress ulcer. These data suggested a heightened activity of the hypothalamic-pituitary axis. Basal plasma ACTH levels did not differ between WKY rats and Wistar rats, but serial plasma ACTH response to restraint stress was significantly greater for WKY rats. These data suggest that depressive behavior is a characteristic of WKY rats and this strain is a valuable model for studying depression which may be induced by an exaggerated stress response.
与其他几种大鼠品系相比，Wistar Kyoto（WKY）大鼠在旷场试验和防御性埋土试验中活动较少。WKY大鼠很容易习得无助任务以及被动回避任务。WKY大鼠对束缚诱导的应激性溃疡也更敏感。行为测试表明WKY大鼠存在抑郁行为。当接受“行为绝望”的波索尔特强迫游泳试验时，WKY大鼠被判定表现出更多的抑郁行为。地昔帕明不仅减少了强迫游泳试验中的不动时间，还减轻了束缚诱导的应激性溃疡的严重程度。这些数据表明下丘脑 - 垂体轴的活性增强。WKY大鼠和Wistar大鼠的基础血浆促肾上腺皮质激素（ACTH）水平没有差异，但WKY大鼠对束缚应激的系列血浆ACTH反应明显更大。这些数据表明抑郁行为是WKY大鼠的一个特征，并且该品系是研究可能由过度应激反应诱导的抑郁症的有价值模型。
