论喹诺酮类药物的作用机制。
On the mechanism of action of quinolone drugs.
作者信息
Palumbo M, Gatto B, Zagotto G, Palù G
机构信息
Dept of Pharmaceutical Sciences, University of Padova, Italy.
出版信息
Trends Microbiol. 1993 Sep;1(6):232-5. doi: 10.1016/0966-842x(93)90138-h.
PMID:8137121
Abstract
Antibacterial quinolones are thought to inhibit DNA gyrase by trapping the enzyme as a complex with the DNA substrate. The precise molecular details of drug-DNA and drug-enzyme interactions remain controversial. Here, a model is proposed that accounts for the influence of magnesium ions on quinolone-DNA binding.
摘要
抗菌喹诺酮类药物被认为是通过将该酶捕获为与DNA底物的复合物来抑制DNA回旋酶。药物与DNA以及药物与酶相互作用的确切分子细节仍存在争议。在此，我们提出了一个模型，该模型解释了镁离子对喹诺酮-DNA结合的影响。
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